Cisplatin hyponatremia

Author: xaby

August undefined, 2024

WebFeb 16, 2024 · Cisplatin Dosage Medically reviewed by Drugs.com. Last updated on Feb 16, 2024. Applies to the following strengths: 50 mg; 10 mg; 1 mg/mL Usual Adult Dose for: Testicular Cancer Ovarian Cancer Bladder Cancer Usual Pediatric Dose for: Testicular Cancer Ovarian Cancer Bladder Cancer Additional dosage information: Renal Dose … WebNational Center for Biotechnology Information

Cisplatin-induced hyponatremia in malignancy: comparison …

WebApr 6, 2024 · Treatment-related grade 3/4 hyponatremia was reported in 5%–7% of MIBC patients treated with pre-operative ... NAC and prolonged survival. 34-36 It is hypothesized that these mutations may increase the sensitivity of tumor cells to cisplatin-induced DNA damage, thereby enhancing the drug's efficacy in these tumors. 37 The incidence of DDR ... WebElectrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management. Platinum chemotherapy, particularly cisplatin, is commonly associated … birth records orlando florida

A Review of Drug-Induced Hyponatremia - ScienceDirect

WebHyponatremia due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) or gastrointestinal loss of sodium is sometimes seen during chemotherapy. However, … WebJul 1, 2008 · Hyponatremia associated with platinum compounds is described more frequently with cisplatin than with carboplatin. 42, 43 The possible underlying pathophysiological mechanisms by which cisplatin induces hyponatremia are SIADH and renal salt wasting. 44 Cisplatin-induced hyponatremia often is combined with … daredevil do you believe in the devil

Differential diagnosis of hyponatremia induced by …

An integrated analysis of hyponatremia in cancer patients …

WebDec 20, 2024 · Background: Hyponatremia is a common electrolyte abnormality in cancer patients who receive chemotherapy. Among anticancer agents, platinum-based agents are reported to cause chemotherapy-induced hyponatremia. However, the actual incidence and risk factors remain unknown. Results: The reports of 29 trials were analyzed. WebSep 15, 2024 · SIDE EFFECTS. Nephrotoxicity - Dose-related and cumulative renal insufficiency is the major dose-limiting toxicity of cis-platin.Renal toxicity has been noted in 28% to 36% of patients treated with a single dose of 50 mg/m 2.It is first noted during the second week after a dose and is manifested by elevations in BUN and creatinine, serum … daredevil fishing spoons glow in the darkWebJul 8, 2010 · Cisplatin based therapy for the treatment of solid organ tumors is commonly associated with several renal abnormalities including; *hypokalemia. * hypomagnesemia. … daredevil film online subtitrat in romana

"WebHyponatremia of grade 3 or above developed in 30.7% of the generic CDDP group compared to 15.1% of the brand-name CDDP group ( P =0.011). Multivariate analysis showed that the use of generic CDDP increased the incidence of hyponatremia (odds ratio =5.661, 95% confidence interval =1.403–22.839; P =0.015). Conclusion: Oncologists … " - Cisplatin hyponatremia

Cisplatin hyponatremia

Neoadjuvant therapy with camrelizumab plus gemcitabine and cisplatin …

Webhyponatremia was reported in 15% and 30.7% of 79 patients receiving brand and generic cisplatin respectively [16]. In our larger cisplatin treated cohort (n=298), all degree hyponatremia and moderate to severe hyponatremia was observed in 14.1% and 10% of patients respectively. In line with previous reports, hyponatremia was also WebKeywords: Cisplatin, Dehydration, Hyponatremia, Renal salt wasting, Siadh. Case Presentation: A 63-year-old male presents to the hospital with complaints of one-day history of weakness, dizziness. His outpatient blood work demonstrated a serum sodium level of 124 mEq/L, and a creatinine of 3.1 mg/dL. His medical history was significant for high ...

Did you know?

WebMay 22, 2012 · The development of hyponatremia during cisplatin therapy bears special mention. Cisplatin stimulates AVP secretion to cause SIADH, but it can also directly damage renal tubules to interfere with sodium reabsorption, which in rare cases may lead to hyponatremia via salt wasting nephropathy [ 41 ]. WebApr 12, 2024 · AKI-related cisplatin may also be associated with tubulopathies, such as Fanconi-like syndrome, hypomagnesemia, salt-loosing syndrome and distal renal tubular acidosis . Tubular dysfunction is characterized by electrolyte disorders such as hyponatremia, hypokalemia and hypomagnesemia.

WebNov 21, 2024 · Cisplatin probably causes hyponatremia by causing SIADH and through its effect on the kidneys. ( 5 Trusted Source A Review of Drug-induced Hyponatremia Go to source) Painkillers: Opiates,... WebApr 7, 2024 · Acute overdosage of spironolactone tablets may be manifested by drowsiness, mental confusion, maculopapular or erythematous rash, nausea, vomiting, dizziness, or diarrhea. Rarely, instances of hyponatremia, hyperkalemia, or hepatic coma may occur in patients with severe liver disease, but these are unlikely due to acute overdosage.

WebMar 24, 2024 · Hyponatremia has been a recognized complication of platinum-based chemotherapy for decades. 7,8 There is limited data to quantify the overall incidence of … WebMay 17, 2024 · Hyponatremia occurs when the concentration of sodium in your blood is abnormally low. Sodium is an electrolyte, and it helps regulate the amount of water that's in and around your cells. In hyponatremia, one or more factors — ranging from an underlying medical condition to drinking too much water — cause the sodium in your body to …

WebMay 19, 2024 · Cisplatin treatment may cause hyponatremia through SIADH, related to both higher secretion of and sensitivity to ADH ( 32 ). Nausea and vomiting, which are common side effects of platinum …

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and neck, bladder, ovarian, and testicular malignancies. 1,2 Approximately 20% of all cancer patients are … daredevil hell\\u0027s kitchenWebJul 22, 2024 · Cisplatin-induced kidney toxicity is reviewed here. The use of cisplatin in patients with pre-existing kidney dysfunction and the kidney effects of the platinum … birth records uk free onlineWebCisplatin-Induced Acute Kidney Injury and Renal Salt Wasting Syndrome. A treatment strategy that incorporates both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. daredevil hell\u0027s kitchenhttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf daredevil female characterWebAug 18, 2024 · Water losses from brain cells cause neurologic symptoms. Volume expansion and dilutional hyponatremia, without neurologic symptoms, can also be induced when isotonic mannitol is used as a flushing solution during transurethral resection of the prostate or bladder. daredevil hallway fight episodeWebMar 23, 2024 · With a median follow-up of 12 months, 25 patients in the first-line group and 15 patients in the second-line group died of UTUC. For cisplatin-ineligible first-line patients, the median OS was 18.0 months (95% CI 4.1–31.9), the 1-year OS rate was 65.4%, and the median PFS was 5.0 months (95% CI 2.0–8.0; Figure 1A,B). daredevil fishing lureWebMar 1, 2024 · Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude of renal disorders including acute kidney injury with reduced glomerular filtration, Fanconi syndrome, and renal tubular acidosis, nephrogenic diabetes insipidus and renal salt wasting syndrome. birth records time of birth