Rnf4 sumo

Author: xfzp

August undefined, 2024

http://yuxiqbs.cqvip.com/Qikan/Search/Index?key=K%3d%e7%a5%9e%e7%bb%8f%e7%b3%bb%e7%bb%9f%e7%96%be%e7%97%85 WebCancer cells overcome cellular senescence by activating the telomere maintenance mechanism, which can be either through telomerase or the alternative lengthening of telomeres (ALT). Being exclusive to cancer cells, targeting ALT is a more promising route for the development of drugs against cancer.

6047 - Gene ResultRNF4 ring finger protein 4 [ (human)]

WebThe SUMO-targeted ubiquitin ligase RNF4 localizes to etoposide-exposed mitotic chromosomes: implication for a novel DNA damage response during mitosis. Masayuki Saito, Yuka Fujimitsu, Takeshi Sasano, Yushi Yoshikai, Reiko Ban-Ishihara, Yuko Nariai, Takeshi Urano, Hisato Saitoh WebEnter the email address you signed up with and we'll email you a reset link. romand glasting

SLX4 assembles nuclear condensates that compartmentalize the …

WebFeb 2, 2012 · Plasmids expressing Maltose Binding Protein-RNF4 (MBP-RNF4), MBP-RNF4 RING mutant (C132/153S), or SUMO-T7-Tax were transformed into BL21 cells under … WebStructural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. C. Kung, M. Naik, +7 authors Tai-Huang Huang; Biology ... WebSep 30, 2024 · The SUMO-Targeted Ubiquitin Ligases (STUbL) mediate this process, and RNF4, the mammalian STUbL, has been at the forefront in the understanding of this … romand dusty pink

RCSB PDB - 4NPN: Crystal structure of human tetra-SUMO-2

SUMO Chain-Induced Dimerization Activates RNF4 - ResearchGate

WebAbstract. Protein ubiquitylation and sumoylation play key roles in regulating cellular responses to DNA double-strand breaks (DSBs). Here, we show that human RNF4, a small … WebRNF4 depletion or proteasome inhibition led to accumulation of mixed, polyubiquitinated, poly-SUMO chains. PML protein accumulated in RNF4-depleted cells and was … romand eyelash curlerWebits selective recognition and ubiquitination of SUMO-modified proteins. Here,we define a key newdeterminant for targetdiscrim-ination by RNF4, in addition to interaction with SUMO. … romand indonesia

"WebSep 18, 2012 · This is consistent with the increased interaction of RNF4 with PML isoforms in response to As 2 O 3, an agent known to induce poly-SUMOylation (as seen in Fig. 1B), … " - Rnf4 sumo

Rnf4 sumo

成相裕子 (Yuko Nariai) - マイポータル - researchmap

WebApr 22, 2013 · Designing SUMO-traps to capture SUMOylated proteins. SUMO-traps, also named SUMO binding entities (SUBEs), were engineered by introducing RNF4-derived … WebRT @MolecularCell: Online Now: Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. 14 Apr 2024 01:06:10

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Web1 hour ago · Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair Web本公开提供了可以介导或诱导蛋白质降解的新分子或构建体。这些分子可以以构建体的形式提供并用于介导特定蛋白的降解。这些分子包含e3连接酶组分和靶蛋白结合部分；这确保了分子可以针对特定蛋白靶标的降解进行定制。

WebJul 3, 2014 · RNF4, which is a SUMO-dependent E3 ubiquitin ligase, binds to the poly-SUMO2/SUMO3 chains via tandem SUMO interacting motifs (SIM) and ubiquitylates the … WebHirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes Cells 19: 743-54 (2014)

WebPML degradation [4,10]. RNF4 was initially described as a SUMO-targeted ubiquitin ligase (STUbL) [21]. This RING finger protein [22] colocalizes with SUMO1 in PML NBs [23] and … WebEnseignement Introduction Si la régulation de l’expression des gènes est un aspect essentiel du développement, celle-ci fait également partie intégrante de la transformation cancéreuse. La transcription des gènes fait l’objet de multiples régulations dont les grands principes ont été rappelés. Le cours a ensuite été centré sur l’étude détaillée d’un facteur de ...

WebThe SIM domain contains the four SUMO interaction motifs (SIMs) of RING-finger 4 (RNF4). This SIM domain prefers binding polySUMO chains with four or more SUMOs. It is useful for enrichment of polysumolyated proteins or polySUMO chains. 基 …

WebMar 9, 2024 · We report that SLX4 compartmentalizes the SUMO-RNF4 signaling pathway. SENP6 and RNF4 regulate the assembly and disassembly of SLX4 condensates, … romand grace taupeWebSep 18, 2024 · Similarly, RNF4 has been shown to regulate the SUMO- and ubiquitin-mediated proteasomal degradation of a mutant cystic fibrosis transmembrane … romand juicy 23WebJun 17, 2024 · A tag already exists with the provided branch name. Many Git commands accept both tag and branch names, so creating this branch may cause unexpected behavior. romand glossWebRNF4 Is Relocalized to SUMO-Containing Nuclear Bodies in Response to SENP6 Depletion (A) HeLa YFP-SUMO-2 cells were treated with siNT, siSENP6, or siRNF4. SUMO … romand juicyWebOnline Now: Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. 13 Apr 2024 14:55:02 romand inner lighting cushionWebJun 29, 2010 · Here we show that RNF4 (RING finger protein 4), a SUMO-dependent ubiquitin E3-ligase previously implicated in maintaining genome stability, plays a key role in active … romand juicy lastingWebComparative and Molecular Biosciences PhD Program Dr. Anja-Katrin Bielinsky's Laboratory “MCM10 and RNF4 protect the integrity of the genome by preventing DNA under-replication” romand juicy lasting tint 18