Ufmylation在文献中是什么意思
Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene. UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 and E2-like conjugating enzyme UFC1. This process is often referred to as UFMylation. http://cjbmb.bjmu.edu.cn/CN/Y2024/V35/I3/229
Ufmylation在文献中是什么意思
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Web21 Dec 2024 · Here we demonstrated that (1) an ER membrane-localizing reductase, CYB5R3, is a bona fide UFM1 substrate; (2) ufmylated CYB5R3 interacts with the E3 ligase component UFBP1 to facilitate further ... Web19 Sep 2024 · The UFL1/UFBP1 complex is an atypical scaffold-type ligase that activates aminolysis by the UFM1-conjugating E2 enzyme. CDK5RAP3 regulates activity of the UFL1/UFBP1 E3 ligase complex and promotes mono-UFMylation of ribosomes. Activity of the E2 UFC1 is regulated by an N-terminal extension and a unique TAK motif.
Web19 Sep 2024 · Besides ubiquitin (Ub), humans have a set of ubiquitin-like proteins (UBLs) that can also covalently modify target proteins. To date, less is known about UBLs than Ub and even less is known about the UBL called ubiquitin-fold modifier 1 (UFM1). Currently, our understanding of protein modification by UFM1 (UFMylation) is like a jigsaw puzzle with … Web39 ubiquitin-like modifier conjugation system called ufmylation, UFL1, as one of the proteins 40 recruited to membranes at ER-mitochondrial contact sites in response to RIG-I activation. 41 Here, we show that UFL1, as well as the process of ufmylation, promote IFN induction in 42 response to RIG-I activation.
Web9 Mar 2024 · UFMylation of PD-L1 destabilizes PD-L1 by synergizing its ubiquitination. Inhibition of PD-L1 UFMylation via silencing of UFL1 or Ubiquitin-fold modifier 1 (UFM1), … WebUFMylation修饰（UFM1修饰）是最新被鉴定的一种类泛素化修饰【2,3】，与泛素化修饰类似，UFM1以前体形式被合成，经过UfSP1或UfSP2剪切，形成活化的UFM1-G83后被一个特定的E1样活化酶（UBA5）激活，转 …
Web1 Oct 2024 · The Ubiquitin-fold modifier 1 (Ufm1) is a ubiquitin-like protein that can also be conjugated to protein substrates and subsequently alter their fates.Both UFMylation and de-UFMylation are mediated by Ufm1-specific proteases (UFSPs).In humans, it is widely believed that UFSP2 is the only active Ufm1 protease involved in Ufm1 maturation and de …
WebThough the function of ufmylation in ER stress and autophagy has been described in mammals, their detailed roles in plant development and stress responses remain elusive. … strength perfect in weaknessWebHaving found that the E3 ligase of ufmylation, UFL1, is recruited to MAVS signaling sites at the MAM in response to RIG-I signaling (), we wanted to determine if UFL1 regulates RIG-I signaling.To test this, we measured induction of the IFN-β promoter following UFL1 overexpression using an IFN-β promoter luciferase reporter assay and found that UFL1 … strength pareto evolutionary algorithm 2http://www.ichacha.net/fabulation.html strength pills gncWebUbiquitin-fold modifier 1 (UFM1) is a recently identified ubiquitin-like posttranslational modification with important biological functions. However, the regulatory mechanisms … strength platinum pokemonWebThe Ubiquitin-fold modifier 1 (Ufm1) is a ubiquitin-like protein that can also be conjugated to protein substrates and subsequently alter their fates. Both UFMylation and de-UFMylation are mediated by Ufm1-specific proteases (UFSPs). In humans, it is widely believed that UFSP2 is the only active Ufm1 protease involved in Ufm1 maturation and de-UFMylation, … strength plus speedhttp://www.ebiotrade.com/newsf/2024-2/2024221154447540.htm strength persona guide p5rWeb2024年3月10日，加州大学伯克利分校Jacob E. Corn研究组在Cell上发表文章A Genome-wide ER-Phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation，针对内质网自噬以ER-phagy报告基因为筛选背景展开了全基因基础的筛选，发现并鉴定出200多个与人类内质网自噬相关的因子，揭开了内质网自噬依赖于 ... strength potential ndis